Structure of PDB 8a0g Chain B Binding Site BS01

Receptor Information
>8a0g Chain B (length=344) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATN
FGRAVQQVNAMIEKKLEPLQSRRPLTSCTIFLGYTSNLISSGIRETIRYL
VQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNL
LVPNENYCKFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPES
VYYWAQKNHIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQ
AIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGA
RPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFM
Ligand information
Ligand ID13D
InChIInChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2
InChIKeyXFNJVJPLKCPIBV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CN)CN
ACDLabs 10.04
CACTVS 3.341		NCCCN
FormulaC3 H10 N2
Name1,3-DIAMINOPROPANE
ChEMBLCHEMBL174324
DrugBank
ZINCZINC000005828682
PDB chain8a0g Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8a0g Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.
Resolution1.84 Å
Binding residue
(original residue number in PDB)		G239 S240 D243
Binding residue
(residue number reindexed from 1)		G220 S221 D224
Annotation score5
Enzymatic activity
Enzyme Commision number 2.5.1.46: deoxyhypusine synthase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0034038 deoxyhypusine synthase activity
GO:0042802 identical protein binding
Biological Process
GO:0006412 translation
GO:0008216 spermidine metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0042102 positive regulation of T cell proliferation
GO:0042593 glucose homeostasis
GO:0046203 spermidine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a0g, PDBe:8a0g, PDBj:8a0g
PDBsum8a0g
PubMed36973244
UniProtP49366|DHYS_HUMAN Deoxyhypusine synthase (Gene Name=DHPS)

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