Structure of PDB 7zwk Chain B Binding Site BS01

Receptor Information

>7zwk Chain B (length=153) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLDP
YWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIFK
TKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAITQ
GKR

Ligand information

>7zwk Chain C (length=7) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KGGGFKK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7zwk Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2162
Resolution	2.0 Å
Binding residue (original residue number in PDB)	H51 D129 Y130 A132 S135 G151 N152 G153 V155 Y161
Binding residue (residue number reindexed from 1)	H34 D112 Y113 A115 S118 G134 N135 G136 V138 Y144

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:7zwk, PDBe:7zwk, PDBj:7zwk
PDBsum	7zwk
PubMed
UniProt	Q32ZE1\|POLG_ZIKV Genome polyprotein

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