Structure of PDB 7zv8 Chain B Binding Site BS01

Receptor Information

>7zv8 Chain B (length=300) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2)

SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTPNYED
LLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRI
QPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDC
VSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLA
WLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQ
TGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ

Ligand information

>7zv8 Chain D (length=3) Species: 32630 (synthetic construct)

GFH

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7zv8 Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2.
• Resolution: 1.937 Å
• Binding residue (original residue number in PDB): F140 N142 G143 S144 C145 H163 H164 M165 E166
• Binding residue (residue number reindexed from 1): F134 N136 G137 S138 C139 H157 H158 M159 E160

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.50: mRNA guanylyltransferase.
  3.1.13.-
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.4.22.69: SARS coronavirus main proteinase.
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.
  4.6.1.-

Gene Ontology

Molecular Function

• GO:0008233 peptidase activity

Biological Process

• GO:0019082 viral protein processing

External links

• PDB: RCSB:7zv8, PDBe:7zv8, PDBj:7zv8
• PDBsum: 7zv8
• PubMed: 36332548
• UniProt: P0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)