Structure of PDB 7zg4 Chain B Binding Site BS01

Receptor Information
>7zg4 Chain B (length=148) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWI
FVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand IDIQL
InChIInChI=1S/C6H8N4/c1-8-5(7)6-9-3-2-4-10-6/h2-4H,1H3,(H2,7,8)
InChIKeyGXUPAQKJNPTPOU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		CNC(=N)c1ncccn1
OpenEye OEToolkits 2.0.7[H]/N=C(\c1ncccn1)/NC
FormulaC6 H8 N4
NameN-methylpyrimidine-2-carboximidamide;
N'-methylpyrimidine-2-carboximidamide
ChEMBLCHEMBL5170116
DrugBank
ZINC
PDB chain7zg4 Chain B Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zg4 Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution2.01 Å
Binding residue
(original residue number in PDB)		K416 S417 D422 W432 C433 W486 W491 D528
Binding residue
(residue number reindexed from 1)		K16 S17 D22 W32 C33 W86 W91 D128
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7zg4, PDBe:7zg4, PDBj:7zg4
PDBsum7zg4
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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