Structure of PDB 7zez Chain B Binding Site BS01
Receptor Information
>7zez Chain B (length=64) Species:
9606
(Homo sapiens) [
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AKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNL
PESVAYTCVNCTER
Ligand information
>7zez Chain D (length=13) Species:
9606
(Homo sapiens) [
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ARTKQTARKSTGG
Receptor-Ligand Complex Structure
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PDB
7zez
RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.
Resolution
N/A
Binding residue
(original residue number in PDB)
Y1576 D1580 Y1581 M1585 C1588 D1592 W1594 Y1607 L1610 S1611 L1613 V1617
Binding residue
(residue number reindexed from 1)
Y13 D17 Y18 M22 C25 D29 W31 Y44 L47 S48 L50 V54
Enzymatic activity
Enzyme Commision number
2.1.1.-
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:7zez
,
PDBe:7zez
,
PDBj:7zez
PDBsum
7zez
PubMed
37075125
UniProt
Q03164
|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)
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