Structure of PDB 7zep Chain B Binding Site BS01

Receptor Information
>7zep Chain B (length=827) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLVVEPSYPDLVINVGEVTLGEENRKKLQKIQRDQEKERVMRAACALLNS
GGGVIRMAKKVEHPVEMGLDLEQSLRELIQSSDLQAFFETKQQGRCFYIF
VKSWSSGPFPEDRSVKPRLCSLSSSLYRRSETSVRSMDSREAFCFLKTKR
KPDPADLIFQKDYLEYGEILPFPASQLVEFKQFSTKHFQEYVKRTIPEYV
PAFANTGGGYLFIGVDDKSREVLGCAKENVDPDSLRRKIEQAIYKLPCVH
FCQPQRPITFTLKIVNVLKRGELYGYACMIRVNPFCCAVFSEAPNSWIVE
DKYVCSLTTEKWVGMMTDVYSKKGLEHKKELQQLLFSVPPGYLRYTPESL
WRDLISEHRGLEELINKQMQPFFRGILIFSRSWAVDLNLQEKPGVICDAL
LIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKVCVRA
KVLCLSPVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLSDQLGCE
VLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHC
EAHRILYVCENQPLRNFISDRNICRAETRKTFLRENFEHIQHIVIDEAQN
FRTEDGDWYGKAKSITRRAKGGPGILWIFLDYFQTSHLDCSGLPPLSDQY
PREELTRIVRNADPIAKYLQKEMQVIRSNPSFNIPTGCLEVFPEAEWSQG
VQGTLRIKKYLTVEQIMTCVADTCRRFFDRGYSPKDVAVLVSTAKEVEHY
KYELLKAMRKKRVVQLSDACDMLGDHIVLDSVRRFSGLERSIVFGIHPRT
ADPAILPNVLICLASRAKQHLYIFPWG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7zep Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zep Mechanistic understanding of human SLFN11.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H285 C321
Binding residue
(residue number reindexed from 1)		H250 C286
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0002376 immune system process
GO:0006338 chromatin remodeling
GO:0006974 DNA damage response
GO:0008156 negative regulation of DNA replication
GO:0043111 replication fork arrest
GO:0051607 defense response to virus
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0090734 site of DNA damage

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7zep, PDBe:7zep, PDBj:7zep
PDBsum7zep
PubMed36115853
UniProtQ7Z7L1|SLN11_HUMAN Schlafen family member 11 (Gene Name=SLFN11)

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