Structure of PDB 7z5m Chain B Binding Site BS01

Receptor Information
>7z5m Chain B (length=148) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWI
FVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand ID5ZK
InChIInChI=1S/C7H9N5/c1-4-5-6(12-11-4)7(8-2)10-3-9-5/h3H,1-2H3,(H,11,12)(H,8,9,10)
InChIKeySUUWWTXOJILAMU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7Cc1c2c(c(ncn2)NC)[nH]n1
CACTVS 3.385CNc1ncnc2c(C)n[nH]c12
FormulaC7 H9 N5
Name~{N},3-dimethyl-1~{H}-pyrazolo[4,3-d]pyrimidin-7-amine
ChEMBLCHEMBL5177286
DrugBank
ZINCZINC000041527945
PDB chain7z5m Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z5m Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		K416 S417 Y418 D422 W432 C433 W486 W491 D528
Binding residue
(residue number reindexed from 1)		K16 S17 Y18 D22 W32 C33 W86 W91 D128
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7z5m, PDBe:7z5m, PDBj:7z5m
PDBsum7z5m
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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