Structure of PDB 7z52 Chain B Binding Site BS01

Receptor Information
>7z52 Chain B (length=706) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQR
EAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALS
NQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMRE
VAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEW
ICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNT
AMQVLRDAGSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFN
TDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPI
LKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWI
SSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSA
FHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKDIKSAK
RELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADEL
LLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQ
ECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMT
DVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVF
AASLYL
Ligand information
Receptor-Ligand Complex Structure
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PDB7z52 Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		K192 E230 R262 F394 S395 K396 G457 T484 F504 R999
Binding residue
(residue number reindexed from 1)		K97 E135 R167 F282 S283 K284 G345 T372 F392 R663
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0000460 maturation of 5.8S rRNA
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0006974 DNA damage response
GO:0008380 RNA splicing
GO:0016076 snRNA catabolic process
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0031499 TRAMP complex
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z52, PDBe:7z52, PDBj:7z52
PDBsum7z52
PubMed35688157
UniProtP42285|MTREX_HUMAN Exosome RNA helicase MTR4 (Gene Name=MTREX)

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