Structure of PDB 7z4h Chain B Binding Site BS01 |
| >7z4h Chain B (length=1334) Species: 1314 (Streptococcus pyogenes)
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DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGAL
LFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRL
EESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADL
RLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPI
NASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPN
FKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAIL
LSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIF
FDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRK
QRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYY
VGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKN
LPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDL
LFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKII
KDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQL
KRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDS
LTFKEDIQKAQVSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKP
ENIVIEMARENNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLY
YLQNGRDMYVDQELDINRLSDYDVDAIVPQSFLKDDSIDNKVLTRSDKNR
GKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKA
GFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVS
DFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYV
RKMIAAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGR
DFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDP
KKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNP
IDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELAL
PSKYVNFLYLASHYESPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVIL
ADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTID
RKRYTSTKEVLDATLIHQSITGLYETRIDLSQLG |
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| PDB | 7z4h R-loop formation and conformational activation mechanisms of Cas9. |
| Resolution | 3.49 Å |
Binding residue
(original residue number in PDB) | K30 K33 L35 R40 K44 N46 G56 E57 T58 A59 T62 R63 K65 R66 R69 R70 R71 R74 K76 N77 R78 Y81 L101 S104 F105 R115 H116 I122 E125 H129 T134 I135 H160 K163 F164 R165 G166 H167 Y325 H328 H329 L332 K336 R340 F351 F352 Y359 I363 K401 Q402 R403 T404 F405 N407 G408 I448 Y450 G453 P454 L455 A456 R457 N459 S460 F462 W464 T472 I473 P475 H721 K735 L738 Q739 K742 R753 Y981 P1090 Q1091 K1097 E1099 V1100 T1102 G1103 G1104 F1105 I1110 R1122 K1123 K1124 K1130 Y1131 F1134 M1169 E1225 L1226 A1227 Q1272 H1349 Q1350 S1351 Y1356 T1358 |
Binding residue
(residue number reindexed from 1) | K29 K32 L34 R39 K43 N45 G55 E56 T57 A58 T61 R62 K64 R65 R68 R69 R70 R73 K75 N76 R77 Y80 L100 S103 F104 R114 H115 I121 E124 H128 T133 I134 H159 K162 F163 R164 G165 H166 Y324 H327 H328 L331 K335 R339 F350 F351 Y358 I362 K400 Q401 R402 T403 F404 N406 G407 I447 Y449 G452 P453 L454 A455 R456 N458 S459 F461 W463 T471 I472 P474 H715 K729 L732 Q733 K736 R747 Y967 P1062 Q1063 K1069 E1071 V1072 T1074 G1075 G1076 F1077 I1082 R1094 K1095 K1096 K1102 Y1103 F1106 M1141 E1197 L1198 A1199 Q1240 H1317 Q1318 S1319 Y1324 T1326 |
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