Structure of PDB 7z0s Chain B Binding Site BS01

Receptor Information

>7z0s Chain B (length=170) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MNRFVIADSTLCIGCHTCEAACSETHRQHGLQSMPRLRVMLNEKESAPQL
CHHCEDAPCAVVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAIEFS
GSRPLDIPANANTPKAPPAPPAPARVSTLLDWVPGIRAIAVKCDLCSFDE
QGPACVRMCPTKALHLVDNT

Ligand information

InChI=1S/4Fe.4S

LJBDFODJNLIPKO-UHFFFAOYSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 2.0.7	[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385	S1[Fe]S[Fe]1.S2[Fe]S[Fe]2

Formula

Fe4 S4

Name

IRON/SULFUR CLUSTER

ChEMBL

DrugBank

ZINC

PDB chain

7z0s Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7z0s Structure of the membrane-bound formate hydrogenlyase complex from Escherichia coli.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	C12 I13 G14 C15 H16 T17 C18 P48 C159 P160 T161 L164
Binding residue (residue number reindexed from 1)	C12 I13 G14 C15 H16 T17 C18 P48 C159 P160 T161 L164
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0006007	glucose catabolic process
GO:0009061	anaerobic respiration
GO:0015944	formate oxidation
GO:0019645	anaerobic electron transport chain

	Cellular Component
GO:0009326	formate dehydrogenase complex

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Cellular Component

External links

PDB	RCSB:7z0s, PDBe:7z0s, PDBj:7z0s
PDBsum	7z0s
PubMed	36104349
UniProt	P0AAK1\|HYCB_ECOLI Formate hydrogenlyase subunit 2 (Gene Name=hycB)

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