Structure of PDB 7yzo Chain B Binding Site BS01

Receptor Information
>7yzo Chain B (length=368) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRILHTSDWHLGQNFYSKSREAEHQAFLDWLLETAQTHQVDAIIVAGDVF
DTGSPPSYARTLYNRFVVNLQQTGCHLVVLAGNQDSVATLNESRDIMAFL
NTTVVASAGHAPQILPRRDGTPGAVLCPIPFLRPRDILLAAITDYYQQHY
ADACKLRGDQPLPIIATGHLTTVGASKSDAVRDIYIGTLDAFPAQNFPPA
DYIALGHIHRAQIIGGMEHVRYCGSPIPLSFDECGKSKYVHLVTFSNGKL
ESVENLNVPVTQPMAVLKGDLASITAQLEQWRDVSQEPPVWLDIEITTDE
YLHDIQRKIQALTESLPVEVLLVRRSRETLSELSVEEVFNRRLALEELDE
SQQQRLQHLFTTTLHTLA
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7yzo Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7yzo Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D8 H10 D48 H222 H224
Binding residue
(residue number reindexed from 1)		D8 H10 D48 H207 H209
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:1990238 double-stranded DNA endonuclease activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006274 DNA replication termination
GO:0006281 DNA repair
GO:0006310 DNA recombination
Cellular Component
GO:1990391 DNA repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yzo, PDBe:7yzo, PDBj:7yzo
PDBsum7yzo
PubMed35987200
UniProtP0AG76|SBCD_ECOLI Nuclease SbcCD subunit D (Gene Name=sbcD)

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