Structure of PDB 7yx6 Chain B Binding Site BS01

Receptor Information
>7yx6 Chain B (length=148) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWI
FVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand IDI6R
InChIInChI=1S/C6H8N2O2/c1-2-4-3-5(9)8-6(10)7-4/h3H,2H2,1H3,(H2,7,8,9,10)
InChIKeyJKUXMZDHLUUPGG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		CCC1=CC(=O)NC(=O)N1
FormulaC6 H8 N2 O2
Name6-ethyl-1H-pyrimidine-2,4-dione
ChEMBLCHEMBL5171838
DrugBank
ZINCZINC000001689128
PDB chain7yx6 Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7yx6 Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		S417 Y418 D422 W432 C433 W486 W491
Binding residue
(residue number reindexed from 1)		S17 Y18 D22 W32 C33 W86 W91
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7yx6, PDBe:7yx6, PDBj:7yx6
PDBsum7yx6
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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