Structure of PDB 7yuv Chain B Binding Site BS01

Receptor Information
>7yuv Chain B (length=532) Species: 172827 (Meiothermus taiwanensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSDLEALRKKIEEVGMPEAVKTKALKELDRLERMQQGSPEATVARTYLDW
LTEVPWSKADPEVLDINHTRQVLDEDHYGLKDVKERILEYLAVRQLTQGL
DVRNKAPILVLVGPPGVGKTSLGRSIARSMNRKFHRISLGGVRDEAEIRG
HRRTYIGAMPGKLIHAMKQVGVINPVILLDEIDKMSSDWRGDPASAMLEV
LDPEQNNTFTDHYLDVPYDLSKVFFITTANTLQTIPRPLLDRMEVIEIPG
YTNMEKQAIARQYLWPKQVRESGMEGRIEVTDAAILRVISEYTREAGVRG
LERELGKIARKGAKFWLEGAWEGLRTIDASDIPTYLGIPRYRPDKAETEP
QVGTAQGLAWTPVGGTLLTIEVAAVPGSGKLSLTGQLGEVMKESAQAALT
YLRAHTQDYGLPEDFYNKVDLHVHVPDGATPKDGPSAGITMATAIASALS
RRPARMDIAMTGEVSLRGKVMPIGGVKEKLLAAHQAGIHKIVLPKDNEAQ
LEELPKEVLEGLEIKLVEDVGEVLEYLLLPEP
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7yuv Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yuv A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		H319 P357 G358 V359 G360 K361 T362 Y493 I501 K509 V540 R541
Binding residue
(residue number reindexed from 1)		H77 P115 G116 V117 G118 K119 T120 Y251 I259 K267 V298 R299
Annotation score5
Enzymatic activity
Enzyme Commision number 3.4.21.53: endopeptidase La.
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
GO:0008236 serine-type peptidase activity
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0030163 protein catabolic process
GO:0034605 cellular response to heat
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yuv, PDBe:7yuv, PDBj:7yuv
PDBsum7yuv
PubMed37957149
UniProtA0A059VAZ3

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