Structure of PDB 7yfh Chain B Binding Site BS01

Receptor Information
>7yfh Chain B (length=652) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVTVAVVFGSSGPLQTQARTRLTSQNFLDLPLEIQPLTVGVNNTNPSSIL
TQICGLLGAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAV
VLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALF
LEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAYC
SREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFPVGLISVVT
ESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAR
EAFYRHLLNVTWEGRDFSFSPGGYLVRPTMVVIALNRHRLWEMVGRWDHG
VLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVP
NTVPCRRQSNHTFSSGDLTPYTKLCCKGFCIDILKKLAKVVKFSYDLYLV
TNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVE
TGISVMVSRSDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYR
DMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVT
IGSGKVFATTGYGIAMQKDSHWKRAIDLALLQLLGDGETQKLETVWLSGI
CQ
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain7yfh Chain B Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yfh Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		H483 S509 T511 R516 G686 S687 T688 Y728
Binding residue
(residue number reindexed from 1)		H455 S481 T483 R488 G539 S540 T541 Y581
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7yfh, PDBe:7yfh, PDBj:7yfh
PDBsum7yfh
PubMed36959261
UniProtQ00961|NMDE3_RAT Glutamate receptor ionotropic, NMDA 2C (Gene Name=Grin2c)

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