Structure of PDB 7yev Chain B Binding Site BS01

Receptor Information
>7yev Chain B (length=1073) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPTASSGHGYQCHVCSAVLFSPLDLDAHVASHGLHGDVENRKTAQLLHAD
TPRLVTWDAGLCTSFKIVPIVPAQVPQDVLAYTFFTSSYAIQSPFPEAAV
SRIVVHTRWASNVDFDRDSSVIMAPPTENNIHLFKQLLNTETLSVRGANP
LMFRANVLHMLLEFVLDNLYLNRHTGFSQDHTPFTEGANLRSLPGPDAEK
WYSIMYPTRMGTPNVSKICNFVASCVRNRVGRFDRAQMMNGAMSEWVDVF
ETSDALTVSIRGRWMARLARMNINPTEIEWALTECAQGYVTVTSPYAPSV
NRLMPYRISNAERQISQIIRVMNIGNNATVIQPVLQDISVLLQRISPLQI
DPTIISNTMSTVSESTTQTLSPASSILGKLRPSNSDFSSFRVALAGWLYN
GVVTTVIDDSSYPKDGGSVTSLENLWDFFILALALPLTTDPCAPVKAFMT
LANMMVGFETIPMDNQIYTQSRRASAFSTPHTWPRCFMNIQLISPIDAPI
LRQWAEIIHRYWPNPSQIRYGTPNVFGSANLFTPPEVLLLPIDHQPANVT
TPTLDFTNELTNWRARVCELMKNLVDNQRYQPGWTQSLVSSMRGTLGKLK
LIKSMTPMYLQQLAPVELAVIAPMLPFPPFQVPYVRLDRDRVPTMVGVTR
QSRDTITQPALSLSTTNTTVGVPLALDARAITVALLSGKYPPDLVTNVWY
ADAIYPMYADTEVFSNLQRDVITCEAVQTLVTLVAQISETQYPVDRYLDW
IPSLRASAATAATFAEWVNTSMKTAFDLSDMLLEPLLSGDPRMTQLAIQY
QQYNGRTFNVIPEMPGSVIADCVQLTAEVFNHEYNLFGIARGDIIIGRVQ
STHLWSPLAPPPDLVFDRDTPGVHIFGRDCRISFGMNGAAPMIRDETGMM
VPFEGNWIFPLALWQMNTRYFNQQFDAWIKTGELRIRIEMGAYPYMLHYY
DPRQYANAWNLTSAWLEEITPTSIPSVPFMVPISSDHDISSAPAVQYIIS
TEYNDRSLFCTNSSSPQTIAGPDKHIPVERYNILTNPDAPPTQIQLPEVV
DLYNVVTRYAYETPPITAVVMGV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7yev Chain B Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yev In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C183 H199 H203
Binding residue
(residue number reindexed from 1)		C12 H28 H32
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0019028 viral capsid
GO:0039625 viral inner capsid

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7yev, PDBe:7yev, PDBj:7yev
PDBsum7yev
PubMed36469786
UniProtC9E874

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