Structure of PDB 7y7r Chain B Binding Site BS01

Receptor Information

>7y7r Chain B (length=897) Species: 5141 (Neurospora crassa)

AALRNIWPKFPKWHEAPLAVAWEVTRFMHKVDSLGLKYDPSTARDVTDIE
KPPNDVFVTAMTGNFESKGSAVVLSAVLDYNPDNSPLYLVKLKPLMFEQG
CRLTRRFGPDRFFEILIPSPTSSPSVPPVSKQAVEEVIQWLTMGQHSLVG
RQWRAFFAKDAGYRKPPIIKERVHFFAETGITFRPDEPVEQRTEFKVSQM
LDWLLQLDNNTWQPHLKLFSRIQLGLSKTYAIMTLEPHQIRHHKTDLLSP
SGTGEVMNDGVGRMSRSVAKRIRDVLGLGDVPSAVQGRFGSAKGMWVIDV
DDTGDEDWIETYPSQRKWECDFVDKHQRTLEVRSVASELKSAGLNLQLLP
VLEDRARDKVKMRQAIGDRLINDLQRQFSEQKHALNRPVEFRQWVYESYS
SRATRVSHGRVPFLAGLPDSQEETLNFLMNSGFDPKKQKYLQDIAWDLQK
RKCDTLKSKLNIRVGRSAYIYMIADFWGVLEENEVHVGFSSKFRDEESFT
LLSDCDVLVARSPAHFPSDIQRVRAVFKPELHSLKDVIIFSTKGDVPLAK
KLSGGDYDGDMAWVCWDPEIVDGFVNAEMPLEPDLSRYLKKDKTTFKQLM
ASHGTGSAAKEQTTYDMIQKSFHFALQPNFLGMCTNYKERLCYINNSVSN
KPAIILSSLVGNLVDQSKQGIVFNEASWAQLRRELLGGALSLPDPMYKSD
SWLGRGEPTHIIDYLKFSIARPAIDKELEAFHNMKAADGAHFWDPDLASY
YTFFKEISDKSRSSALLFTTLKNRIGEVEKEYGRLVKKEDPYPVRVNQVY
EKWCAITPSKVIRLLELSFLADREMNTWALLRASTAFKLYYHKSPKFVWQ
MAGRQLAYIKAQMTSRPGEGAPALMTAFMYAGLMPDKKFTKQYVARL

Ligand information

>7y7r Chain E (length=12)

aactaccgtcgg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7y7r Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): K790 Y919 G1083 T1086 N1087 R1091 R1133 S1142
• Binding residue (residue number reindexed from 1): K340 Y469 G632 T635 N636 R640 R682 S691

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity

External links

• PDB: RCSB:7y7r, PDBe:7y7r, PDBj:7y7r
• PDBsum: 7y7r
• PubMed: 36039765
• UniProt: Q9Y7G6