Structure of PDB 7y7p Chain B Binding Site BS01

Receptor Information

>7y7p Chain B (length=908) Species: 5141 (Neurospora crassa)

VAARLRNIWPKFPKWLHEAPLAVAWEVTRLFMHCKVDLELKYDPSWSTAR
DVTDIWKTLYRLEKPPNDVFVTAMTGNFESKGSAVVLSAVLDYNPDNSPA
PLYLVKLKPLMFEQGCRLTRRFGPDRFFEILIPSPTSTSPSVPPVVSKQP
AVEEVIQWLTMGQHSLVGRQWRAFFAKDAGYRKPLRPIIKERVHFFAETG
ITFRPDEPVEQRTEFKVSQMLDWLLQLDNNTWQPHLKLFSRIQLGLSKTY
AIMTLEPHQIRHHKTDLLSPSGTGEVMNDGVGRMSRSVAKRIRDVLGLGD
VPSAVQGRFGSAKGMWVIDVDDTGDEDWIETYPSQRKWECDFVDKHQRTL
EVRSVASELKSAGLNLQLLPVLEDRARDKVKMRQAIGDRLINDLQRQFSE
QKHALNRPVEFRQWVYESYSSRATRVSHGRVPFLAGLPDSQEETLNFLMN
SGFDPKKQKYLQDIAWDLQKRKCDTLKSKLNIRVGRSAYIYMIADFWGVL
EENEVHVGFSSKFRDEEESFTLLSDCDVLVARSPAHFPSDIQRVRAVFKP
ELHSLKDVIIFSTKGDVPLAKKLSGGDYDGDMAWVCWDPEIVDGFVNAEM
PLEPDLSRYLKKDKTTFKQLMASHGTGSAAKEQTTYDMIQKSFHFALQPN
FLGMCTNYKERLCYINNSVSNKPAIILSSLVGNLVDQSKQGIVFNEASWA
QLRRELLGGALSLPDPMYKSDSWLGRGEPTHIIDYLKFSIARPAIDKELE
AFHNAEDGAHFWDPDLASYYTFFKEISDKSRSSALLFTTLKNRIGEVEKE
YGRPVRVNQVYEKWCAITPESKVIRLLELSFLADREMNTWALLRASTAFK
LYYHKSPKFVWQMAGRQLAYIKAQMTSRPGEGAPALMTAFMYAGLMPDKK
FTKQYVAR

Ligand information

>7y7p Chain E (length=11)

cuauggucgga

...........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7y7p Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): Y590 N795 Y919 S963 M1012 L1082 G1083 M1084 N1087 R1091
• Binding residue (residue number reindexed from 1): Y181 N365 Y489 S533 M582 L652 G653 M654 N657 R661

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity

External links

• PDB: RCSB:7y7p, PDBe:7y7p, PDBj:7y7p
• PDBsum: 7y7p
• PubMed: 36039765
• UniProt: Q9Y7G6