Structure of PDB 7xgj Chain B Binding Site BS01

Receptor Information
>7xgj Chain B (length=165) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFFPRKPKWDKNQITYRIIGYTPDLAPETVDDAFARAFQVWSDVTPLRFS
RIYDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDD
ELWTLGKGVGYSLFLVAAHAFGHAMGLEHSQDPGALMAPIYTYTKNFRLS
QDDIKGIQELYGASP
Ligand information
Receptor-Ligand Complex Structure
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PDB7xgj Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		F5 Y74 H85 A86 F87 V118 H121 H125 H131 L138 A140 P141 I142
Binding residue
(residue number reindexed from 1)		F3 Y72 H83 A84 F85 V116 H119 H123 H129 L136 A138 P139 I140
Enzymatic activity
Enzyme Commision number 3.4.24.24: gelatinase A.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xgj, PDBe:7xgj, PDBj:7xgj
PDBsum7xgj
PubMed35687819
UniProtP08253|MMP2_HUMAN 72 kDa type IV collagenase (Gene Name=MMP2)

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