Structure of PDB 7xdx Chain B Binding Site BS01

Receptor Information
>7xdx Chain B (length=280) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CRHFAFAEIKAATKNFDESRVLGVGGFGKVYRGEIDGGTTKVAIKRGNPM
SEQGVHEFQTEIEMLSKLRHRHLVSLIGYCEENCEMILVYDYMAHGTMRE
HLYKTQNPSLPWKQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLD
EKWVAKVSDFGLSKTSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEALCAR
PALNPTLAKEQVSLAEWAPYCYKKGMLDQIVDPYLKGKITPECFKKFAET
AMKCVLDQGIERPSMGDVLWNLEFALQLQE
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7xdx Chain B Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7xdx The Structural and Biochemical Basis for FER Receptor Kinase Early Signaling Initiation in Arabidopsis
Resolution2.23 Å
Binding residue
(original residue number in PDB)		L542 V550 A563 D611 Y612 M613 G616 E620 L668 D679
Binding residue
(residue number reindexed from 1)		L22 V30 A43 D91 Y92 M93 G96 E100 L148 D159
Annotation score5
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7xdx, PDBe:7xdx, PDBj:7xdx
PDBsum7xdx
PubMed36774537
UniProtQ9SCZ4|FERON_ARATH Receptor-like protein kinase FERONIA (Gene Name=FER)

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