Structure of PDB 7xbk Chain B Binding Site BS01

Receptor Information

>7xbk Chain B (length=351) Species: 9606 (Homo sapiens)

KREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVF
LFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSP
PGYVGHEEGGQLTKKLKQCPNAVVLFDQVDKAHPDVLTIMLQLFDEGRLT
DGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGD
VQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELI
QLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVE
RRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLPKLRLEIIDKDSKTRRL
D

Ligand information

>7xbk Chain L (length=17) Species: 9606 (Homo sapiens)

AAAAAAAAAAAAAAAAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7xbk Comprehensive structural characterization of the human AAA+ disaggregase CLPB in the apo- and substrate-bound states reveals a unique mode of action driven by oligomerization.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): G399 Y400 V401
• Binding residue (residue number reindexed from 1): G102 Y103 V104

Enzymatic activity

• Enzyme Commision number: 3.6.1.-

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0140545 ATP-dependent protein disaggregase activity

Biological Process

• GO:0030851 granulocyte differentiation
• GO:0034605 cellular response to heat
• GO:0039529 RIG-I signaling pathway
• GO:0140374 antiviral innate immune response

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005758 mitochondrial intermembrane space

External links

• PDB: RCSB:7xbk, PDBe:7xbk, PDBj:7xbk
• PDBsum: 7xbk
• PubMed: 36745679
• UniProt: Q9H078|CLPB_HUMAN Mitochondrial disaggregase (Gene Name=CLPB)