Structure of PDB 7x05 Chain B Binding Site BS01

Receptor Information
>7x05 Chain B (length=801) Species: 1094619 (Phytophthora sojae strain P6497) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPPSIRSCGSQQYVTSYIPTGAAFPPSSVQDMISSMKSYASATDLVRTYS
EIPSVEEALSTLDRAAAALNARRYRDALKLYLEGGYAMANVAERQANPKI
CNLLTSKGFETLNWCARLCDWIEGRIKEKHPRPGVHKVGIPVSNWDEDWV
GPFMDEEEARRMWYTPVYCPHPIDFSNLGYRLRCVETGRRPRLMICITMY
NEGPQQLKATLKKLANNLAYLKEQMPGDEKSLTGAFAGDDVWQNVLVCIV
ADGREQVHPKTLDYLEAIGLYDEDLLTINSAGIGAQCHLFEHTLQLSVNG
KCLLPIQTVFALKENKASKLDSHHWYFNAFAEQIQPEYTAVMDVGTMLTK
SALYHLLFAFERNHQIGGACGQLTVDNPFENLSNWVISAQHFEYKISNIL
DKSLESCFGFISVLPGAFSAYRYEAIRGAPLDAYFQTLNIELDVLGPFIG
NMYLAEDRILSFEVVARKNCNWTMHYVKDAVARTDVPHDLVGLISQRKRW
LNGAFFATLFSIWNWGRIYSESKHTFVRKMAFLVFYVYHLLYTAFGFFLP
ANLYLALFFIVFQGFQQNRLEFIDTSEYSQTVLDCAVYIYNFSYLFGLLM
LIIIGLGNNPKHMKLTYYFVGAVFGLMMMLSSLVGAGIFFSTPATVHSIV
VSILTVGVYFIASALHGEVHHIFMTFTHYTALIPSFVNIFTIYSFCNLQD
LSKGDFKDVIAKRRALEELRREEKERVENRKKNFEAFRTNVLLTWAFSNL
IFALFVVYFASSSTYMPVLYIFVASLNTCRLLGSIGHWVYIHTEGLRGRV
I
Ligand information
Ligand IDUDP
InChIInChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyXCCTYIAWTASOJW-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.370O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.370O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
FormulaC9 H14 N2 O12 P2
NameURIDINE-5'-DIPHOSPHATE
ChEMBLCHEMBL130266
DrugBankDB03435
ZINCZINC000004490939
PDB chain7x05 Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7x05 Structural basis for directional chitin biosynthesis.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		Y239 D291 D382
Binding residue
(residue number reindexed from 1)		Y200 D252 D343
Annotation score3
Enzymatic activity
Enzyme Commision number 2.4.1.16: chitin synthase.
Gene Ontology
Molecular Function
GO:0004100 chitin synthase activity
GO:0016757 glycosyltransferase activity
GO:0016758 hexosyltransferase activity
Biological Process
GO:0006031 chitin biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005886 plasma membrane
GO:0030428 cell septum
GO:0071944 cell periphery

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7x05, PDBe:7x05, PDBj:7x05
PDBsum7x05
PubMed36131020
UniProtG4Z2L3

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