Structure of PDB 7wxi Chain B Binding Site BS01

Receptor Information
>7wxi Chain B (length=430) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVEVMAENARTGSRQMQALTPAQRASAVNTLADLLVSREKFILDANAKDL
AEAQKSGLAKPLLSRLSLNPAKLKNLSVGLKQIAEDSHKNVGRVLRRTRL
ADQLELKQVTVPIGVLLVIFESRPDSLPQVAALAMASANGLLLKGGKEAA
HSNKALMELVKEALATVGAEHAVSLVSTREEISDLLSMENHIDLIIPRGS
SDLVRSIQQQSLHIPVLGHAEGVCHVYIDRDADLEKALRIARDAKCDYPA
ACNAMETLLIHEDLMSGAIFGDVCNMLKREGVKIYAGPRLNQQLTFGPPA
AKSLKHEYGALECCIEVVPSLDEAINHIHTYGSSHTDVIVTENDAAARQF
LGSVDSACVFHNASSRFADGFRFGLGAEVGISTARIHARGPVGVEGLLTT
KWILEGQDHAAADFAEGGGRTWLHETLPLD
Ligand information
Ligand IDRGP
InChIInChI=1S/C5H10NO7P/c6-3(5(8)9)1-2-4(7)13-14(10,11)12/h3H,1-2,6H2,(H,8,9)(H2,10,11,12)/t3-/m1/s1
InChIKeyPJRXVIJAERNUIP-GSVOUGTGSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCC(=O)O[P](O)(O)=O)C(O)=O
ACDLabs 10.04O=C(OP(=O)(O)O)CCC(C(=O)O)N
OpenEye OEToolkits 1.5.0C(CC(=O)OP(=O)(O)O)C(C(=O)O)N
CACTVS 3.341N[C@H](CCC(=O)O[P](O)(O)=O)C(O)=O
OpenEye OEToolkits 1.5.0C(CC(=O)OP(=O)(O)O)[C@H](C(=O)O)N
FormulaC5 H10 N O7 P
NameGAMMA-GLUTAMYL PHOSPHATE;
5-OXO-5-(PHOSPHONOOXY)-D-NORVALINE
ChEMBL
DrugBank
ZINCZINC000003870044
PDB chain7wxi Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7wxi Structural basis of dynamic P5CS filaments.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		R712 D715
Binding residue
(residue number reindexed from 1)		R366 D369
Annotation score5
Enzymatic activity
Enzyme Commision number 1.2.1.41: glutamate-5-semialdehyde dehydrogenase.
2.7.2.11: glutamate 5-kinase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004349 glutamate 5-kinase activity
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0006561 proline biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0016310 phosphorylation
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wxi, PDBe:7wxi, PDBj:7wxi
PDBsum7wxi
PubMed35286254
UniProtQ9VNW6

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