Structure of PDB 7vbc Chain B Binding Site BS01

Receptor Information
>7vbc Chain B (length=1123) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGL
GLAVQAIPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECR
GRRSTYRGKLTADINWAVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQ
ALIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPG
YTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIYRKELFFLPLGFALK
ALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQVLNYL
GECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLF
ALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKA
QKTSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLC
VVADKLNFIRYLSHFRCVHRGADFAKMRTTTVRRLLPESWGFLCPVHTPD
GEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECY
PVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKP
SLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAG
VTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQ
DRSDNKLYRLQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDME
DAMIVNKASWERGFAHGSVYKSEFIDLSEKIKQGDSSLVFGIKPGDPRVL
QKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMYYKSKENCVVDNIKV
CSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPF
TESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSE
ENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRH
MVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLL
HDRLFNCSDRSVAHVCVKCGSLLSPLLEKPNRKYNCTLCSRSDTIDTVSV
PYVFRYFVAELAAMNIKVKLDVV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7vbc Structure of the human RNA polymerase I elongation complex.
Resolution3.01 Å
Binding residue
(original residue number in PDB)		R180 Q694 K882 K890 H1004
Binding residue
(residue number reindexed from 1)		R176 Q690 K878 K886 H1000
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0007566 embryo implantation
GO:0009303 rRNA transcription
GO:0014029 neural crest formation
GO:0017126 nucleologenesis
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vbc, PDBe:7vbc, PDBj:7vbc
PDBsum7vbc
PubMed34671025
UniProtQ9H9Y6|RPA2_HUMAN DNA-directed RNA polymerase I subunit RPA2 (Gene Name=POLR1B)

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