Structure of PDB 7v9p Chain B Binding Site BS01

Receptor Information
>7v9p Chain B (length=845) Species: 405948 (Saccharopolyspora erythraea NRRL 2338) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPNLTREQAEQRAALLEVQSYAIELDLSAVETFGSTTTVRFRSATPGAES
WIDLVAARVRSAVLNGVELDVSDYDESTGIRLPELAADNELVVHADCQYT
NTGEGLHRFIDPVDGGVYLYSQFETADAKRMFTCFDQPDLKATYQITVTA
PQDWKVISNAAGEVTDTGEGTRRHVFDTTKPMSTYLVALVAGPYAEWRDV
FPGDDGQDEIPLGIYCRASLAEHLDAERLFIETKQGFGFFHKAFGVPYPF
GKYDQCFVPEFNAGAMENAGCVTFLEDYVFRSRVTGYLYERRSETVLHEM
AHMWFGDLVTMRWWDDLWLNESFATWASVLAQVGATQYTNAWTTFASVEK
SWAYRQDQLPSTHPVAADIPDLQAVTYAKGASVLKQLVAYVGLENFLAGL
KVYFDRHAWGNATLDDLLVALEEASGRDLSWWSAQWLQTTGLNMLRPKLA
IDDEGRFTSFSVLQSPARPGAGEHRTHRLAIGIYDDDPATGELVRTHRVE
LDVTGERTEVPDLVGVHRGKLVLVNDDDLTYCTMRLDPQSLATLIDRIAD
IQESLPRALCWSTAWEMTREAELKARDFVSLVLGSSPTTGIGAESEIGVV
QRVLLQTQTALASYADPAWQPEGWRRFAGRLLELARAAEPGSDHQLAFVN
SLAGSVLGEEQISAMRGWLDGTAPLEGLTVDTDLRWGLLQALVAHGAAGE
AEIDAELERDQTATGRRRAERARSLIPTPEAKEKAWQRAVHDDQLPNAIS
DAIISGFQHPGQRELLASYVRRYFDEIDEVWHRRSSERAQPTVIGLFPSW
AVDEDTVAVADRWLEGEHAPALRRLVSEGRAGIVRALAAREFDRS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7v9p Chain B Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7v9p Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		H306 H310 E329
Binding residue
(residue number reindexed from 1)		H298 H302 E321
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0043171 peptide catabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7v9p, PDBe:7v9p, PDBj:7v9p
PDBsum7v9p
PubMed35513512
UniProtA4F9D7

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