Structure of PDB 7v3p Chain B Binding Site BS01

Receptor Information
>7v3p Chain B (length=816) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKARSYRFPKLTVITE
YLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNL
RNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCP
GCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCS
APDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAES
SDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKT
IDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKI
RHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLT
IKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCES
DVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRG
AKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIV
RWQRQPQDGYLYRHNYCSKDKIPIRKCACPKTEAEKQAEKEEAEYRKVFE
NFLHNSIFVPRPEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAE
KLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGL
ILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLS
GNGSWTDPVFFYVQAK
Ligand information
>7v3p Chain E (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCN
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7v3p Cryo-EM structure of the IGF1R/insulin complex
Resolution3.6 Å
Binding residue
(original residue number in PDB)		N698 P703 R704
Binding residue
(residue number reindexed from 1)		N655 P660 R661
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:7v3p, PDBe:7v3p, PDBj:7v3p
PDBsum7v3p
PubMed
UniProtP08069|IGF1R_HUMAN Insulin-like growth factor 1 receptor (Gene Name=IGF1R)

[Back to BioLiP]