Structure of PDB 7ux8 Chain B Binding Site BS01

Receptor Information
>7ux8 Chain B (length=361) Species: 202862 (Streptomyces drozdowiczii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVSLVDESLLVGVTDEDRAVRSAHQFYERLIGLWAPAVMEAAHELGVFAA
LAEAPADSGELARRLDCDARAMRVLLDALYAYDVIDRIHDTNGFRYLLSA
EARECLLPGTLFSLVGKFMHDINVAWPAWRNLAEVVRHGARDTSGAESPN
GIAQEDYESLVGGINFWAPPIVTTLSRKLRASGRSGDATASVLDVGCGTG
LYSQLLLREFPRWTATGLDVERIATLANAQALRLGVEERFATRAGDFWRG
GWGTGYDLVLFANIFHLQTPASAVRLMRHAAACLAPDGLVAVVDQIVDAD
REPKTPQDRFALLFAASMTNTGGGDAYTFQEYEEWFTAAGLQRIETLDTP
MHRILLARRAT
Ligand information
Ligand IDTYR
InChIInChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKeyOUYCCCASQSFEME-QMMMGPOBSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)Cc1ccc(O)cc1
OpenEye OEToolkits 1.5.0c1cc(ccc1C[C@@H](C(=O)O)N)O
OpenEye OEToolkits 1.5.0c1cc(ccc1CC(C(=O)O)N)O
CACTVS 3.341N[CH](Cc1ccc(O)cc1)C(O)=O
CACTVS 3.341N[C@@H](Cc1ccc(O)cc1)C(O)=O
FormulaC9 H11 N O3
NameTYROSINE
ChEMBLCHEMBL925
DrugBankDB00135
ZINCZINC000000266964
PDB chain7ux8 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ux8 Expanding the eukaryotic genetic code with a biosynthesized 21st amino acid.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		Y32 W39
Binding residue
(residue number reindexed from 1)		Y27 W34
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7ux8, PDBe:7ux8, PDBj:7ux8
PDBsum7ux8
PubMed36173166
UniProtA0A0D4WTP2

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