Structure of PDB 7u6u Chain B Binding Site BS01

Receptor Information
>7u6u Chain B (length=399) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNNFNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKK
HLRWLKALPRVTPFYAVKCNDSKAIVKTLAATRTGFDCASKTEIQLVQSL
GVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKL
VLRIATDVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQ
AISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALD
KYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLEQTFMYYVNDGVY
GSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLP
EMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQN
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain7u6u Chain B Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7u6u Structure and Enzymatic Activity of an Intellectual Disability-Associated Ornithine Decarboxylase Variant, G84R.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		K69 H197 G237 E274 G276 R277 Y389
Binding residue
(residue number reindexed from 1)		K68 H187 G227 E264 G266 R267 Y366
Annotation score1
Enzymatic activity
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001822 kidney development
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0033387 putrescine biosynthetic process from ornithine
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7u6u, PDBe:7u6u, PDBj:7u6u
PDBsum7u6u
PubMed36188294
UniProtP11926|DCOR_HUMAN Ornithine decarboxylase (Gene Name=ODC1)

[Back to BioLiP]