Structure of PDB 7tqq Chain B Binding Site BS01

Receptor Information
>7tqq Chain B (length=213) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPPPTVPPPPR
VVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFL
RRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKAL
ERAKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDA
HARPFGTIRPMYG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tqq Structural basis of human TREX1 DNA degradation and autoimmune disease.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		D18 E20 A21 G23 L24 F26 A80 I84 T85 H124 N125 R128 Y129 K160 R164 S176 Y177 S178 L179
Binding residue
(residue number reindexed from 1)		D11 E13 A14 G16 L17 F19 A68 I72 T73 H112 N113 R116 Y117 K148 R152 S155 Y156 S157 L158
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:7tqq, PDBe:7tqq, PDBj:7tqq
PDBsum7tqq
PubMed35879334
UniProtQ9NSU2|TREX1_HUMAN Three-prime repair exonuclease 1 (Gene Name=TREX1)

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