Structure of PDB 7tl7 Chain B Binding Site BS01

Receptor Information

>7tl7 Chain B (length=526) Species: 6239 (Caenorhabditis elegans)

MAMANNSSVANKVCLIVIDGWGVSEDPYGNAILNAQTPVMDKLCSGNWAQ
IEAHGLHVGLPEGLMGNSEVGHLNIGAGRVIYQDIVRINLAVKNNKFVTN
ESLVDACDRAKNGNGRLHLAGLVSDGGVHSHIDHMFALVKAIKELGVPEL
YLHFYGDGRDTSPNSGVGFLEQTLEFLEKTTGYGKLATVVGRYYAMDRDN
RWERINVAYEAMIGGVGETSDEAGVVEVVRKRYAADETDEFLKPIILQGE
KGRVQNDDTIIFFDYRADRMREISAAMGMDRYKDCNSKLAHPSNLQVYGM
TQYKAEFPFKSLFPPASNKNVLAEWLAEQKVSQFHCAETEKYAHVTFFFN
GGLEKQFEGEERCLVPSPKVATYDLQPEMSAAGVADKMIEQLEAGTHPFI
MCNFAPPDMVGHTGVYEAAVKACEATDIAIGRIYEATQKHGYSLMVTADH
GNAEKMKAPDGGKHTAHTCYRVPLTLSHPGFKFVDPADRHPALCDVAPTV
LAIMGLPQPAEMTGVSIVQKIKLAAA

Ligand information

>7tl7 Chain b (length=13) Species: 32630 (synthetic construct)

YRYEYYKYECPKC

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7tl7 Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): P79 L82 M83 N85 E87 G145 V146 H147 R284 D286 F366 H430 H485
• Binding residue (residue number reindexed from 1): P61 L64 M65 N67 E69 G127 V128 H129 R266 D268 F348 H412 H467

Enzymatic activity

• Enzyme Commision number: 5.4.2.12: phosphoglycerate mutase (2,3-diphosphoglycerate-independent).

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004619 phosphoglycerate mutase activity
• GO:0016853 isomerase activity
• GO:0030145 manganese ion binding
• GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0006007 glucose catabolic process
• GO:0006096 glycolytic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7tl7, PDBe:7tl7, PDBj:7tl7
• PDBsum: 7tl7
• PubMed: 35904259
• UniProt: G5EFZ1|GPMI_CAEEL 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (Gene Name=ipgm-1)