Structure of PDB 7tj5 Chain B Binding Site BS01

Receptor Information
>7tj5 Chain B (length=392) Species: 869211 (Spirochaeta thermophila DSM 6578) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIP
LDLAFESRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSAT
RILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSA
FYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVS
KLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEER
EVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYG
PGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALIL
RAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA
Ligand information
Ligand IDCMP
InChIInChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChIKeyIVOMOUWHDPKRLL-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C4C(O3)COP(=O)(O4)O)O)N
ACDLabs 10.04O=P3(OCC4OC(n1c2ncnc(N)c2nc1)C(O)C4O3)O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)CO[P@](=O)(O4)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH]4CO[P](O)(=O)O[CH]4[CH]3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4CO[P@](O)(=O)O[C@H]4[C@H]3O
FormulaC10 H12 N5 O6 P
NameADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE;
CYCLIC AMP;
CAMP
ChEMBLCHEMBL316966
DrugBankDB02527
ZINCZINC000003873977
PDB chain7tj5 Chain B Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tj5 Anionic lipids unlock the gates of select ion channels in the pacemaker family.
Resolution2.41 Å
Binding residue
(original residue number in PDB)		F366 G367 M369 R377 T378 A379
Binding residue
(residue number reindexed from 1)		F343 G344 M346 R354 T355 A356
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
GO:0044877 protein-containing complex binding
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tj5, PDBe:7tj5, PDBj:7tj5
PDBsum7tj5
PubMed36352139
UniProtG0GA88

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