Structure of PDB 7tj4 Chain B Binding Site BS01

Receptor Information
>7tj4 Chain B (length=176) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLQGKTIVLDPGHGGSDQGASSNTKYKSLEKDYTLKTAKELQRTLEKEGA
TVKMTRTDDTYVSLENRDIKGDAYLSIHNDALESSNANGMTVYWYHDNQR
ALADTLDATIQKKGLLSNRGSRQENYQVLAQTKVPAVLLELGYISNPTDE
TMIKDQLHRQILEQAIVDGLKIYFSA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7tj4 Chain B Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7tj4 Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		H128 E145 H193 D195
Binding residue
(residue number reindexed from 1)		H13 E30 H78 D80
Annotation score4
Enzymatic activity
Enzyme Commision number 3.5.1.-
Gene Ontology
Molecular Function
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
Biological Process
GO:0009253 peptidoglycan catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7tj4, PDBe:7tj4, PDBj:7tj4
PDBsum7tj4
PubMed35733252
UniProtQ2FXU3|LYTH_STAA8 Probable cell wall amidase LytH (Gene Name=lytH)

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