Structure of PDB 7tho Chain B Binding Site BS01

Receptor Information

>7tho Chain B (length=466) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCA
PESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNF
SIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLR
IGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQV
TRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTT
DAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLS
QKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGK
IRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIE
AKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNN
GNGTFECGVCRCGPGW

Ligand information

>7tho Chain M (length=7) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

CRGDWPC

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7tho A general chemical principle for creating closure-stabilizing integrin inhibitors.
Resolution	2.75 Å
Binding residue (original residue number in PDB)	S121 Y122 S123 R214 N215 R216 A218 E220
Binding residue (residue number reindexed from 1)	S121 Y122 S123 R214 N215 R216 A218 E220

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7tho, PDBe:7tho, PDBj:7tho
PDBsum	7tho
PubMed	36113427
UniProt	P05106\|ITB3_HUMAN Integrin beta-3 (Gene Name=ITGB3)

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