Structure of PDB 7t92 Chain B Binding Site BS01

Receptor Information
>7t92 Chain B (length=360) Species: 573729 (Thermothelomyces thermophilus ATCC 42464) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IDEHKPSLFELLSEQQLAALLPPTVRYLLTVLTQRYPRYLLRVLNSFDEL
YALAALVVERHYLRTRGGSFTEHFYGLKRERALVRDALRLRPADVWRNLL
VIVGVPYLKRKLDEAHEADAPRAMMGAAYNRPPLPGAPWRERVAFWWRCF
LRRVYPAVNAAYYLSILAFNLAYLFDNSKYHSPFLCLIGTRVRRMSAADY
RAIEALEERALVLPTSIFALKFLEWWYASDFAKQLSRKAAESLDLPPPVV
AGLPEEEKERRAIERAPVSASSLLPIYTVPPPENSDQCPICEGEITTAAA
CQTGIVYCYPCIHKWLTGTHPRQEKFMAERAGKWESGEGRCAVTGRRVLG
GTEGLRRIMV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7t92 Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7t92 A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C412 C415 C432 C435
Binding residue
(residue number reindexed from 1)		C288 C291 C308 C311
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006513 protein monoubiquitination
GO:0015031 protein transport
GO:0016558 protein import into peroxisome matrix
GO:0016562 protein import into peroxisome matrix, receptor recycling
GO:0016567 protein ubiquitination
Cellular Component
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0016020 membrane
GO:1990429 peroxisomal importomer complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7t92, PDBe:7t92, PDBj:7t92
PDBsum7t92
PubMed35768507
UniProtG2Q5N0|PEX12_THET4 Peroxisome assembly protein 12 (Gene Name=PEX12)

[Back to BioLiP]