Structure of PDB 7t1z Chain B Binding Site BS01
Receptor Information
>7t1z Chain B (length=438) Species:
9606
(Homo sapiens) [
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TQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWR
ILAEDNLLWREKCKEEGIDEPLHIKKPGFIHSPWKSAYIRQHRIDTNWRR
GELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTL
VGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCM
HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSG
AYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWD
VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTL
QGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGG
SGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVD
Ligand information
>7t1z Chain C (length=12) Species:
9606
(Homo sapiens) [
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KKFELLPTPPLS
Receptor-Ligand Complex Structure
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PDB
7t1z
Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Resolution
2.77 Å
Binding residue
(original residue number in PDB)
W425 S462 T463 R465 R479 R505 Y519 L559 S582 L583 A599 S625
Binding residue
(residue number reindexed from 1)
W158 S195 T196 R198 R212 R238 Y252 L292 S315 L316 A332 S358
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7t1z
,
PDBe:7t1z
,
PDBj:7t1z
PDBsum
7t1z
PubMed
35089787
UniProt
Q969H0
|FBXW7_HUMAN F-box/WD repeat-containing protein 7 (Gene Name=FBXW7)
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