Structure of PDB 7t1y Chain B Binding Site BS01
Receptor Information
>7t1y Chain B (length=438) Species:
9606
(Homo sapiens) [
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TQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWR
ILAEDNLLWREKCKEEGIDEPLHIKPGFIHSPWKSAYIRQHRIDTNWRRG
ELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLV
GHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMH
LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGA
YDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDV
ETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQ
GPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS
GGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM
Ligand information
>7t1y Chain C (length=8) Species:
9606
(Homo sapiens) [
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HEETPPTT
Receptor-Ligand Complex Structure
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PDB
7t1y
Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Resolution
2.55 Å
Binding residue
(original residue number in PDB)
W425 R441 S462 T463 R465 R479 Y519 L583
Binding residue
(residue number reindexed from 1)
W157 R173 S194 T195 R197 R211 Y251 L315
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7t1y
,
PDBe:7t1y
,
PDBj:7t1y
PDBsum
7t1y
PubMed
35089787
UniProt
Q969H0
|FBXW7_HUMAN F-box/WD repeat-containing protein 7 (Gene Name=FBXW7)
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