Structure of PDB 7sp0 Chain B Binding Site BS01

Receptor Information
>7sp0 Chain B (length=244) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKL
ESRALAEIAKAELDDTPMRGRQLRVRFATAALSVRNLSPYVSNELLEEAF
SQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTT
PRPVIVEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYS
QRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANIL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7sp0 Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sp0 Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons.
Resolution1.83 Å
Binding residue
(original residue number in PDB)		H483 E489
Binding residue
(residue number reindexed from 1)		H192 E198
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:7sp0, PDBe:7sp0, PDBj:7sp0
PDBsum7sp0
PubMed36168806
UniProtP23246|SFPQ_HUMAN Splicing factor, proline- and glutamine-rich (Gene Name=SFPQ)

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