Structure of PDB 7sjr Chain B Binding Site BS01

Receptor Information
>7sjr Chain B (length=802) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RYSPVELSAALGLFPPTDEQAAVIAAPPGPLVVIAGAGAGKTETMAARVV
WLVANGFATPSQVLGLTFTRKAAGQLLRRVRTRLARLAGAGSDESATVST
YHAFAGTLLREHGLLLPVEPDTRLLSETELWQLAYDVVCAHPGHLDTEKT
PAAVTAMVLRLSGALAEHLVDTDQLRDTHVELERLVHTQRDRGPSQWLLR
MLATQTERTELVPLIDALHQRMRAEKVMDFGMQMAAAARLAARFPQVGEQ
LRQRFRVVLLDEYQDTGHAQRIALSSLFGGGADDGLALTAVGDPIQSIYG
TNLPRFTTDFPYSDGTPAPTLELRTSWRNPPSTLHVANAVSEEALRPRPD
AEPGTIRCALLNNVAAERDWVADHLARAYHGAIGRGEAAPTAAVLVRRNA
DAAPMAEALTARGVPVEVAGLLAVPEVADLVAMLRLIADPTAGSAVMRIL
TGPRWRFGARDIAALWRRAVELDDRPLGTADIVAQAAPDADTACVADAIC
DPGDAERYSPAGYERIVALGRELTMLRAHLGHPLPELVAEVRRVLGLDAE
ARAARPVAAGWAGTENLDRFSDLVSDFAGHAGASVSALLAYLDAAVEVEN
GLAPAELTVSHDRVQILTVHAAKGLEWQVVAVPHLSARVFPSTTQARTWL
TDASDLPPLLRGDRATESEIGVPVRKILSDKISDHKKSLDQRRVDEERRL
LYVAITRAEDTLLLSGHHWGATESKPRGPSEFLCELKTILEEATCGEIEH
WAPDPPLRDQVVEALWPPVDHVHRGAQLVAAAMAGQEGWAADVDALLAER
ER
Ligand information
Receptor-Ligand Complex Structure
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PDB7sjr Structure-activity relationships at a nucleobase-stacking tryptophan required for chemomechanical coupling in the DNA resecting motor-nuclease AdnAB.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		R81 T118 H120 K167 R214 Q220 F254 R437 N438 H665 Q690 R692 T696 R746
Binding residue
(residue number reindexed from 1)		R70 T100 H102 K149 R190 Q196 F230 R398 N399 H620 Q645 R647 T651 R693
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000725 recombinational repair
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005829 cytosol
GO:0033202 DNA helicase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sjr, PDBe:7sjr, PDBj:7sjr
PDBsum7sjr
PubMed34967418
UniProtI7FZ56

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