Structure of PDB 7seo Chain B Binding Site BS01

Receptor Information
>7seo Chain B (length=93) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHI
LTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYHH
Ligand information
Receptor-Ligand Complex Structure
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PDB7seo Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		Y204 S205 W206 R207 N208 S209 W214 F250 F252 F256
Binding residue
(residue number reindexed from 1)		Y19 S20 W21 R22 N23 S24 W29 F65 F67 F71
Enzymatic activity
Enzyme Commision number 3.4.22.56: caspase-3.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7seo, PDBe:7seo, PDBj:7seo
PDBsum7seo
PubMed35059567
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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