Structure of PDB 7s7b Chain B Binding Site BS01

Receptor Information
>7s7b Chain B (length=351) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DAELRERLRQCEETIEQLRAENQELKRKLNILTRPSGILVNDTKLDGPIL
QILFMNNAISKQYHQEIEEFVSNLVKRFEEQQKNDVEKTSFNLLPQPSSI
VLEEDHKVEESCAIKNNKEAFSVVGSVLYFTNFCLDKLGQPLLNENPQLS
EGWEIPKYHQVFSHIVSLEGQHCFNCGSEEHQMKDCPMPNFQQRYHAEEV
EERFGRFKPGVISEELQDALGVTDKSLPPFIYRMRQLGYPPGWLKEAELE
NSGLALYDGKSVTYDLSKLVNYPGFNISTPRGIPDEWRIFGSIPMQACQQ
KDVFANYLPIPDMSKFATGITPFEFENMAESTGMYLRIRSLLKNSPRNQQ
K
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7s7b Chain B Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7s7b Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.
Resolution4.06 Å
Binding residue
(original residue number in PDB)		C229 C232 H237 C242
Binding residue
(residue number reindexed from 1)		C173 C176 H181 C186
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7s7b, PDBe:7s7b, PDBj:7s7b
PDBsum7s7b
PubMed35688134
UniProtQ6NZY4|ZCHC8_HUMAN Zinc finger CCHC domain-containing protein 8 (Gene Name=ZCCHC8)

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