Structure of PDB 7s6h Chain B Binding Site BS01

Receptor Information
>7s6h Chain B (length=469) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKE
NRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN
FTKYPKKFYPLEIDYGGTKSKLPKPVQDLIKMIFDVESMKKAMYEIDLQK
MPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFG
MKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGDPIDVNYEKLKTDI
KVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPF
KQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMV
SKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGL
GKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKY
LLKLKFNFKTSLWLEHHHH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7s6h Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y570 R587 W589 K600 K621
Binding residue
(residue number reindexed from 1)		Y40 R57 W59 K70 K91
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7s6h, PDBe:7s6h, PDBj:7s6h
PDBsum7s6h
PubMed35793673
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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