Structure of PDB 7s5g Chain B Binding Site BS01

Receptor Information
>7s5g Chain B (length=287) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIPWNLERITPPQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVP
EEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKG
TVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGV
VLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCV
DLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLA
ELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7s5g A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
Resolution2.041 Å
Binding residue
(original residue number in PDB)		P155 W156 D238 D367 I369 T377 C378 F379 V380 S381
Binding residue
(residue number reindexed from 1)		P3 W4 D79 D208 I210 T218 C219 F220 V221 S222
Enzymatic activity
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7s5g, PDBe:7s5g, PDBj:7s5g
PDBsum7s5g
PubMed34704436
UniProtQ8NBP7|PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (Gene Name=PCSK9)

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