Structure of PDB 7rtk Chain B Binding Site BS01

Receptor Information
>7rtk Chain B (length=84) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AASSRAQVLALYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVE
IQTLVNKAKRDLGVIRRQVHIGQLYSTDKLIIEN
Ligand information
Ligand IDEDT
InChIInChI=1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)
InChIKeyKCXVZYZYPLLWCC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)CN(CC(=O)O)CCN(CC(=O)O)CC(=O)O
CACTVS 3.341OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O
OpenEye OEToolkits 1.5.0C(CN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O
FormulaC10 H16 N2 O8
Name{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID
ChEMBLCHEMBL858
DrugBankDB00974
ZINCZINC000019364242
PDB chain7rtk Chain B Residue 108 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7rtk The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y26 R29 E84
Binding residue
(residue number reindexed from 1)		Y25 R28 E83
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0016226 iron-sulfur cluster assembly
GO:0044571 [2Fe-2S] cluster assembly
GO:0044572 [4Fe-4S] cluster assembly
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0016604 nuclear body
GO:0099128 mitochondrial [2Fe-2S] assembly complex
GO:1990221 L-cysteine desulfurase complex
GO:1990229 iron-sulfur cluster assembly complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rtk, PDBe:7rtk, PDBj:7rtk
PDBsum7rtk
PubMed
UniProtQ9HD34|LYRM4_HUMAN LYR motif-containing protein 4 (Gene Name=LYRM4)

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