Structure of PDB 7rtf Chain B Binding Site BS01

Receptor Information
>7rtf Chain B (length=395) Species: 154 (Spirochaeta thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIP
LDLAFLLAPSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQA
SATRILSYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRY
LSAFYWTITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIAS
LVSKLDAAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGY
EEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPV
IYGPGEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMA
LILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELA
Ligand information
Ligand IDCMP
InChIInChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChIKeyIVOMOUWHDPKRLL-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C4C(O3)COP(=O)(O4)O)O)N
ACDLabs 10.04O=P3(OCC4OC(n1c2ncnc(N)c2nc1)C(O)C4O3)O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)CO[P@](=O)(O4)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH]4CO[P](O)(=O)O[CH]4[CH]3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4CO[P@](O)(=O)O[C@H]4[C@H]3O
FormulaC10 H12 N5 O6 P
NameADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE;
CYCLIC AMP;
CAMP
ChEMBLCHEMBL316966
DrugBankDB02527
ZINCZINC000003873977
PDB chain7rtf Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7rtf Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		G367 R377 T378 A379
Binding residue
(residue number reindexed from 1)		G347 R357 T358 A359
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
GO:0044877 protein-containing complex binding
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rtf, PDBe:7rtf, PDBj:7rtf
PDBsum7rtf
PubMed36376326
UniProtG0GA88

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