Structure of PDB 7rfk Chain B Binding Site BS01

Receptor Information
>7rfk Chain B (length=575) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DISQDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKTLKNHDIIK
NPYPRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIH
RHILNYCIYGADIDEKAISILKDSLTNKKVVNDLDESDIKINLFCCDSLK
KKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYK
KIIDILKQGGIGSVITPRYFLESLSGKDLREYIKSNVNVQEIVDFLGANI
FKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICINKFETLEELLKSSKF
EHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYSLEDIAISFQGIITGC
DKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEYRLIYSNDIDN
ENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKKIM
YPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVY
DKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLN
KSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB7rfk Repurposing epigenetic inhibitors to target the Clostridioides difficile- specific DNA adenine methyltransferase and sporulation regulator CamA.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		K25 Y30 N165 Y168 H171 K193 Y221 S227 F253 I256 G257 Q346 I431 R432 W439 R441 K456 Y476 K511 M513 S514 Y521 P522 N523
Binding residue
(residue number reindexed from 1)		K23 Y28 N163 Y166 H169 K191 Y219 S225 F251 I254 G255 Q344 I429 R430 W437 R439 K454 Y474 K509 M511 S512 Y519 P520 N521
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7rfk, PDBe:7rfk, PDBj:7rfk
PDBsum7rfk
PubMed34523387
UniProtQ183J3

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