Structure of PDB 7r5w Chain B Binding Site BS01

Receptor Information
>7r5w Chain B (length=150) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWI
FVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHT
Ligand information
Ligand IDI5Z
InChIInChI=1S/C7H8N2O2/c10-6-3-5(4-1-2-4)8-7(11)9-6/h3-4H,1-2H2,(H2,8,9,10,11)
InChIKeyABHXYFPEQCXJJJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7C1CC1C2=CC(=O)NC(=O)N2
CACTVS 3.385O=C1NC(=O)C=C(N1)C2CC2
FormulaC7 H8 N2 O2
Name6-cyclopropyl-1H-pyrimidine-2,4-dione
ChEMBLCHEMBL5192478
DrugBank
ZINCZINC000096300508
PDB chain7r5w Chain B Residue 605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7r5w Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		S417 Y418 D422 W432 C433 W486 W491
Binding residue
(residue number reindexed from 1)		S17 Y18 D22 W32 C33 W86 W91
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7r5w, PDBe:7r5w, PDBj:7r5w
PDBsum7r5w
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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