Structure of PDB 7r5f Chain B Binding Site BS01

Receptor Information
>7r5f Chain B (length=149) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWI
FVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKH
Ligand information
Ligand IDI3V
InChIInChI=1S/C5H7N3O2/c1-2-3(6)4(9)8-5(10)7-2/h6H2,1H3,(H2,7,8,9,10)
InChIKeyFNSSATCDUXTALE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CC1=C(C(=O)NC(=O)N1)N
CACTVS 3.385CC1=C(N)C(=O)NC(=O)N1
FormulaC5 H7 N3 O2
Name5-azanyl-6-methyl-1~{H}-pyrimidine-2,4-dione
ChEMBLCHEMBL5180641
DrugBank
ZINCZINC000000399478
PDB chain7r5f Chain B Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7r5f Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		S417 Y418 D422 W432 C433 S434 W486 W491
Binding residue
(residue number reindexed from 1)		S17 Y18 D22 W32 C33 S34 W86 W91
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7r5f, PDBe:7r5f, PDBj:7r5f
PDBsum7r5f
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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