Structure of PDB 7qta Chain B Binding Site BS01

Receptor Information

>7qta Chain B (length=264) Species: 510516 (Aspergillus oryzae RIB40)

WGNLGHETVAYIAQSFVASSTESFCQNILGDDSTSYLANVATWADTYKYT
DAGEFSKPYHFIDAQDNPPQSCGVDYDRDCGSAGCSISAIQNYTNILLES
PNGSEALNALKFVVHIIGDIHQPLHDENLEAGGNGIDVTYDGETTNLHHI
WDTNMPEEAAGGYSLSVAKTYADLLTERIKTGTYSSKKDSWTDGIDIKDP
VSTSMIWAADANTYVCSTVLDDGLAYINSTDLSGEYYDKSQPVFEELIAK
AGYRLAAWLDLIAS

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7qta Chain B Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qta Atomic resolution studies of S1 nuclease complexes reveal details of RNA interaction with the enzyme despite multiple lattice-translocation defects.
• Resolution: 1.06 Å
• Binding residue (original residue number in PDB): W21 H26 D139
• Binding residue (residue number reindexed from 1): W1 H6 D119
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.30.1: Aspergillus nuclease S1.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004518 nuclease activity
• GO:0004519 endonuclease activity
• GO:0016788 hydrolase activity, acting on ester bonds
• GO:0046872 metal ion binding

Biological Process

• GO:0006308 DNA catabolic process

Cellular Component

• GO:0005575 cellular_component

External links

• PDB: RCSB:7qta, PDBe:7qta, PDBj:7qta
• PDBsum: 7qta
• PubMed: 36189740
• UniProt: P24021|NUS1_ASPOR Nuclease S1 (Gene Name=nucS)