Structure of PDB 7qp0 Chain B Binding Site BS01

Receptor Information

>7qp0 Chain B (length=264) Species: 5478 (Nakaseomyces glabratus)

GMVRPPSSIQQGNGQQFQYSQMTGRRKALLIGINYIGSKNALRGCINDAH
NIFNYLTTYCGYRPEDIVMLTDDQREMVKIPLKENIIRAMQWLVKDAQPN
DALFFHYSGHGGQTKDLDGDEEDGMDDVIYPVDFESVGPLIDDTMHDIMV
KSLPQGARLTALFDSCHSGTVLDLPYTYSTKGVIKEPKFSPADVIMLSGS
KDTFADGQNIGAMSHAFISVMTRQPQQSYLSLLQNLRNELAGKYSQKPQL
SASHPIDVNLQFIM

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7qp0 Chain B Residue 404

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qp0 Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium.
• Resolution: 1.6 Å
• Binding residue (original residue number in PDB): D188 D190
• Binding residue (residue number reindexed from 1): D116 D118
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.22.-

Gene Ontology

Molecular Function

• GO:0004197 cysteine-type endopeptidase activity
• GO:0004198 calcium-dependent cysteine-type endopeptidase activity
• GO:0008234 cysteine-type peptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
• GO:0006915 apoptotic process

Cellular Component

• GO:0005634 nucleus
• GO:0005829 cytosol

External links

• PDB: RCSB:7qp0, PDBe:7qp0, PDBj:7qp0
• PDBsum: 7qp0
• PubMed: 36316540
• UniProt: Q6FPX9|MCA1_CANGA Metacaspase-1 (Gene Name=MCA1)