Structure of PDB 7qot Chain B Binding Site BS01

Receptor Information
>7qot Chain B (length=355) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSED
PTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLD
MKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKH
TQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVM
APDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRI
KKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQK
LCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGY
TLRLC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qot Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.
Resolution3.24 Å
Binding residue
(original residue number in PDB)		K103 I105 N106 Y107 S109 T132 A134 H143 L148 H151 V166 N196
Binding residue
(residue number reindexed from 1)		K102 I104 N105 Y106 S108 T131 A133 H142 L147 H150 V165 N195
Enzymatic activity
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Gene Ontology
Cellular Component
GO:0005576 extracellular region

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Biological Process
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Cellular Component
External links
PDB RCSB:7qot, PDBe:7qot, PDBj:7qot
PDBsum7qot
PubMed30801944
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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