Structure of PDB 7qbu Chain B Binding Site BS01

Receptor Information
>7qbu Chain B (length=407) Species: 2214 (Methanosarcina acetivorans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEVVVDVGGNPGVDCKGFCKYCYFKKVKDIQPLGCKYCLPFKKGCDYCTR
SSYSGFKSLQMVLEETANKLYFTSGEVKKFTVSGGGDLSCYPELKSLITF
LSQFNTPIHLGYTSGKGFSKPDDALFYIDNGVTEVSFTVFATDPALRAEY
MKDPEPEASIQVLRDFCTHCEVYGAIVLLPGINDGEVLEKTLCDLENMGA
KGAILMRFANFQENGLILNNSPIIPGITPHTVSEFTEIVRSSAEKHPSIR
ITGTPLEDPLIGSPFAIRNVPEALLKLPRVSKKATIITGQVAASRLTEIF
EALGGTVNVIPVKKDIGCLITIDDFKALDLSEVTETVFIPGRAFVHDMEI
KEALRRDGVDRIVRRGPERLSVDGEMSIGMTREEVLELEVENFTELIGQI
NSLGLPL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7qbu Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qbu Crystallographic snapshots of a B 12 -dependent radical SAM methyltransferase.
Resolution2.298 Å
Binding residue
(original residue number in PDB)		P11 G12 C15 F18 C19 C22 Y115 S117
Binding residue
(residue number reindexed from 1)		P11 G12 C15 F18 C19 C22 Y112 S114
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.379: [methyl coenzyme M reductase]-L-arginine C-5-methyltransferase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008168 methyltransferase activity
GO:0035244 protein-arginine C-methyltransferase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0032259 methylation
GO:0043687 post-translational protein modification

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7qbu, PDBe:7qbu, PDBj:7qbu
PDBsum7qbu
PubMed35110733
UniProtQ8THG6|MCRAM_METAC [Methyl coenzyme M reductase]-L-arginine C-5-methyltransferase (Gene Name=MA_4551)

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